When your genes had to choose which disease to fight - David Reich
Dwarkesh Patel294 字 (约 2 分钟)
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Genetic variants face evolutionary trade-offs: the TYK2 variant once protected humans against ancient diseases but became a risk factor for severe tuberculosis after its spread, revealing the inherent conflict in immune system optimization.
入选理由：TYK2基因变体频率在6000-3000年前从极低升至9-10%，随后3000年内骤降，显示双向自然选择
FeaturedVideo#population genetics#immune evolution#natural selection#tuberculosis#genetic archaeology英文