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2:29:07 Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests!The Diary Of A CEO and David Sinclair 3.5M views • 4 weeks ago Live Playlist ()Mix (50+)12:17 Shrimp Forever | Trump: I Would Have Won Vietnam | Jet Fuel Running Low The Late Show with Stephen Colbert 709K views • 7 hours ago Live Playlist ()Mix (50+)16:08 Daraxonrasib Hits 58% Response Rate in First-Line Pancreatic Cancer Combination • Revolution Secu...BioMed Nexus 1 view • 1 hour ago Live Playlist ()Mix (50+)19:30 If YOU Take Supplements, You NEED To See This The Diary Of A CEO Clips 1M views • 9 months ago Live Playlist ()Mix (50+)25:04 The Oil Shock Is About To Hit America Andrei Jikh 2.5M views • 1 day ago Live Playlist ()Mix (50+)14:11 Trump Extends Iran Ceasefire Again, Reads from Bible & Tucker Carlson Apologizes for Supporting Him Jimmy Kimmel Live 1.1M views • 7 hours ago Live Playlist ()Mix (50+)1:10:34 This Is What Exercise Actually Does to Your Brain Louisa Nicola and Kavin Mistry, M.D.4.7K views • 22 hours ago Live Playlist ()Mix (50+)19:27 The REAL Reason Trump Started The Iran War The Diary Of A CEO Clips 102K views • 16 hours ago Live Playlist ()Mix (50+)21:01 Before You Buy Magnesium Glycinate Again, Watch THIS (FOOD Works 20x Better) | Dr. William Li Bio Bites 82K views • 8 days ago Live Playlist ()Mix (50+)25:27 The New Fed Chair's Plan to Cancel America's $39T Debt Crisis Minority Mindset 1.3M views • 1 day ago Live Playlist ()Mix (50+)8:22 A New Era in Hungary: Orbán Gets the Boot || Peter Zeihan Zeihan on Geopolitics 9.7K views • 1 hour ago Live Playlist ()Mix (50+)1:26:08 No.1 Nitric Oxide Expert: Why You’re Always Tired and It’s Not Your Fault The Diary Of A CEO 3.4M views • 1 year ago Live Playlist ()Mix (50+)
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259K views 1 day ago#thediaryofaceo#doac
259,151 views • Apr 20, 2026 • #thediaryofaceo #doac
Harvard geneticist Dr David Sinclair reveals his complete supplement stack and explains the science behind why taking certain supplements every other day is more effective than taking them daily. He describes how mice given resveratrol every other day lived significantly longer than those given it daily, and why this principle of pulsing applies to metformin, berberine, and oth…...more
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If YOU Take Daily Supplements, You NEED To See This
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@TheDiaryOfACEOClips @TheDiaryOfACEOClips1 day ago
Watch the full episode here - https://youtu.be/DnvWAP99r3Y
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[@MarcosCapixaba](http://www.youtube.com/@MarcosCapixaba)
Here is summary: *!Image 12: ⚡ Core Principle:* Pulse everything (stress → recover). Don't do the same inputs daily. *!Image 13: 🍷 Key Examples:* - Resveratrol / Metformin → take **every other day**, not daily - Exercise → *lose your breath* for 5 min, 3x/week (aerobic > just weights) *!Image 14: 🔥 Top Therapies:* - Sauna → proven to lower heart disease & mortality - Cold plunge → less proof, but feels good for mental clarity *!Image 15: 💊 Safest Supplements (no downside):* - Spermidine, Glycine (5g), Vitamin D+K2, NMN *!Image 16: 🩸 One Key Test:* Check *Lp(a)* – if high, use high-dose Niacin. *!Image 17: 🔮 Future:* Blindness & paralysis will be curable in our lifetime (gene therapy). *!Image 18: 🥇 #1 Priority:* Skip meals (intermittent fasting).
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[@MarcelGodfrey](http://www.youtube.com/@MarcelGodfrey)
I have stage 4 Liver disease decompensated, I tell myself every day: “ Marcel hold on, fight, a cure is coming !Image 20: 🕊️
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[@redrock1963](http://www.youtube.com/@redrock1963)
One of the things I like about David Sinclair is that he's comfortable to say............. "we don't know".
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[@FREE2BEUS](http://www.youtube.com/@FREE2BEUS)
People need to seriously stop, self obsessing over health. These channels are making a fortune out of your insecurities. If you want to be healthy and actually enjoy life, not spend your days self obsessing, then Get quality sleep. Move regularly, Drink water keep away from processed foods, and use recreational products respectfully and in moderation. That's it. You will live as long if not longer and more importantly, be happier than those falling into the traps these channels create.
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[@IcceVideos](http://www.youtube.com/@IcceVideos)
00:00 – 00:34 – Pulsing (stress & recovery cycles) The body benefits from cycles of stress and recovery, not constant daily inputs. Example: resveratrol worked better in mice when given every other day, not daily. 00:34 – 01:14 – Resveratrol findings In fat mice, daily resveratrol improved health and lifespan (15–20% longer). In normal mice, daily had little effect, but every-other-day dosing significantly extended lifespan in old mice. 01:14 – 01:49 – Metformin & pulsing Metformin can reduce workout performance and muscle size (~5% less) because it interferes with mitochondrial energy production. Pulsing (cycling) metformin is better for longevity. 01:49 – 02:40 – Berberine & exercise timing Berberine is a natural alternative to metformin. Taking it every other day is better, and avoid taking it hours before working out. 02:40 – 03:15 – Exercise & telomeres A CDC study found regular jogging (30 min, 5 days/week) correlates with telomeres looking 10 years younger. Causation is unclear, but controlled trials support exercise lengthening telomeres. 03:15 – 03:52 – Telomeres vs. epigenetics Telomeres were once a key biological age marker, but now DNA methylation (epigenome) is considered a better "clock." 03:52 – 04:31 – Sauna benefits Saunas are proven beneficial for heart disease and mortality. Mechanism unknown, but heat shock proteins may defend cells. 04:31 – 05:13 – Sauna study evidence Finnish studies show regular sauna bathing reduces death from heart disease and cardiovascular events. 05:13 – 05:48 – Cold plunges Limited data, but hormesis (adversity making you feel better) and possible muscle repair benefits. Improves mental clarity and feeling better. 05:48 – 06:30 – Top priority for longevity #1: Skipping meals. #2: Exercise that makes you lose your breath (can't hold a conversation) for at least 5 minutes, 3x/week. Aerobic exercise is linked to longevity. 06:30 – 07:11 – Red light therapy Initially skeptical, but evidence shows certain red light wavelengths rejuvenate mitochondria. He uses a red light cap for hairline preservation. 07:11 – 08:23 – Supplement stack (safe ones) NMN, resveratrol, metformin or berberine, spermidine. 08:23 – 09:36 – Spermidine Extends lifespan in worms to mice, stimulates autophagy (protein recycling), delays epigenetic information loss. Very safe. 09:36 – 11:03 – Glycine Takes ~5 grams daily. May control one-carbon metabolism and DNA methylation, slowing epigenetic aging. Very safe, no downside. 11:03 – 11:46 – Vitamin D & K2 Prevents deficiency, reduces cancer risk. K2 helps keep calcium out of arteries and into bones. 11:46 – 13:08 – Aspirin Takes baby aspirin daily despite changed guidelines. For him, benefits (prevents clotting, stroke, heart attack) outweigh risks (stomach bleeding) due to high cardiovascular risk. 13:08 – 14:34 – LP(a) & niacin LP little A is a genetic risk factor for heart disease. High-dose vitamin B3 (niacin) lowers it, though causes flushing. Takes half a gram daily. 14:34 – 15:52 – Hair loss treatments Red light cap (proven to slow loss). Blocks DHT (hormone that causes male hair loss). Does NOT take testosterone. 15:52 – 17:03 – Testosterone advice Build muscle naturally (legs, back) to raise testosterone. Most men don't need replacement. Testosterone doesn't improve longevity, only health/strength. 17:03 – 19:59 – Future of rejuvenation medicine Predicts curing blindness, reversing organ aging, restoring memory within our lifetimes. His lab reverses tissue age in mice in weeks using three rejuvenation genes. 19:59 – 22:06 – How gene delivery works Uses virus-like particles (AAV2) as delivery vehicles. Targets specific tissues (eye, liver, brain) via surface proteins. Cost ~$10 million to produce, but will become cheap pills. Awaiting FDA approval for first human trial in blind patients.
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[@myriamita](http://www.youtube.com/@myriamita)
Thank you for these short and digestable bits of information. When I see the 2 hours or more long videos, even when I'm interested in the topic, I either check to see if someone in the comments has posted a summary or I just click away.
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[@Sungthing](http://www.youtube.com/@Sungthing)
I am so sick of the title on these videos. Be on the point. I found myself clicking around the video.
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[@LongevityCodeChannel1](http://www.youtube.com/@LongevityCodeChannel1)
What makes Sinclair's supplement stack particularly striking when viewed through the centenarian data is that almost every compound he describes was being delivered through food in the populations with the longest documented healthspans — without any awareness of the mechanisms involved. The spermidine he takes as a supplement exists in natto at concentrations among the highest ever measured in any food — the Okinawan centenarians consuming natto several times weekly were getting consistent spermidine delivery that stimulated the autophagy pathway he describes. The glycine for DNA methylation control arrives in the highest concentrations from collagen-rich whole fish broth and fish skin — exactly the preparation the Japanese centenarians used, consuming small fish whole rather than filleted. The vitamin D and K2 combination he describes as keeping calcium out of arteries and into bones maps directly onto the dietary pattern of Loma Linda Adventists — outdoor walking in California sun for D3, fermented soy and edamame for K2 in the MK-4 form. The berberine as natural metformin alternative finds its food equivalent in the bitter melon — goya — that Okinawan centenarians consumed several times weekly and that activates AMPK through the same pathway berberine targets. Sinclair is describing the mechanisms. The centenarians were living them through breakfast.
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[@rodrigsantsil](http://www.youtube.com/@rodrigsantsil)
I threw away all my resveratrol when I was told by a reputable doctor that it was based on a FAKE study in Spain in the 90's and that it can give you some SERIOUS LUNG problems! And, yes, I was experiencing some weird symptoms in them when I threw them out.
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[@MarlonGabriel-p1w](http://www.youtube.com/@MarlonGabriel-p1w)
I’m a doctor, and ‘The lost secret of healing’ by Noah Rivers is one of the rare books that can truly transform people's lives. Nothing else compares.
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[@Araoke007](http://www.youtube.com/@Araoke007)
Sauna challenge - some us live in places where the heat indoors and outdoors is equivalent to being in a sauna!!!
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[@TheMatazza](http://www.youtube.com/@TheMatazza)
Taking a mitochondrial poison every second day gets better results than taking it every day. In shock.
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[@robertfoertsch](http://www.youtube.com/@robertfoertsch)
Excellent, Deployed Worldwide Through The TRUTH Network… Thank You !Image 32: 🙏!Image 33: ❤
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[@BigNekox](http://www.youtube.com/@BigNekox)
Loving the tips from this longevitymaxer guy GG
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[@Liciablyth](http://www.youtube.com/@Liciablyth)
I love hearing from researchers who are steeped in their work and love what they are doing. The fact that humanity benefits from their work is another bonus. We have what we have now in terms of every field of endeavour because people like Dr Sinclair and Mr Bartlett are fiercely determined to learn and grow and share it! Many thanks for educating us and continuing to push the edge of knowledge further each day.
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[@olegbulls123](http://www.youtube.com/@olegbulls123)
"My father went completely bold by age 30 and completely grey by age 40". WHAT!Image 37: 😂
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[@MrSmith-j7j](http://www.youtube.com/@MrSmith-j7j)
If I follow all or even a fraction of these health and longevity fads, I reckon to get back the time spent on them, for just general 'living' stuff, I would have to live to be 206 years old.
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[@BrettSmith-l9n](http://www.youtube.com/@BrettSmith-l9n)
Fascinating! great video thanks!
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[@HughCook-k4x](http://www.youtube.com/@HughCook-k4x)
Thank you David Sinclair..
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If YOU Take Daily Supplements, You NEED To See This
5.4K Likes
259,151 Views
Apr 20 2026
Harvard geneticist Dr David Sinclair reveals his complete supplement stack and explains the science behind why taking certain supplements every other day is more effective than taking them daily. He describes how mice given resveratrol every other day lived significantly longer than those given it daily, and why this principle of pulsing applies to metformin, berberine, and other longevity supplements. He walks through his personal stack including NMN for fuelling the sirtuin enzymes that control aging, resveratrol as the accelerator pedal for those same enzymes, berberine as a natural alternative to the drug metformin, spermidine for stimulating autophagy and slowing epigenetic information loss, glycine for controlling DNA methylation, vitamin D with K2 to keep calcium out of arteries and into bones, and high-dose niacin to lower a dangerous molecule called Lp(a) that most doctors never test for. Discover: • Why taking supplements every other day works better than daily • The full supplement stack a Harvard aging scientist takes himself • How blind monkeys had their sight restored in six weeks • The molecule called Lp(a) that is as dangerous as cholesterol and most doctors never test • Why the single most important thing for longevity is skipping meals • How sauna bathing is proven to reduce heart disease and early death • The red light cap that is proven to slow hair loss 📺 Watch the full episode here -  ❤️ Subscribe to our main channel -  Get your hands on exclusive Diary of a CEO products: https://thediary.com/collections/all?...#thediaryofaceo#doac…...more
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